Blockade of the C5a–C5aR axis alleviates lung damage in hDPP4-transgenic mice infected with MERS-CoV

The pathogenesis of highly pathogenic Middle East respiratory syndrome coronavirus (MERS-CoV) remains poorly understood. In a previous study, we established an hDPP4-transgenic (hDPP4-Tg) mouse model in which MERS-CoV infection causes severe acute respiratory failure and high mortality accompanied b...

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Udgivet i:Emerg Microbes Infect
Main Authors: Jiang, Yuting, Zhao, Guangyu, Song, Nianping, Li, Pei, Chen, Yuehong, Guo, Yan, Li, Junfeng, Du, Lanying, Jiang, Shibo, Guo, Renfeng, Sun, Shihui, Zhou, Yusen
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5915580/
https://ncbi.nlm.nih.gov/pubmed/29691378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41426-018-0063-8
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