Stemness, Pluripotentiality, and Wnt Antagonism: sFRP4, a Wnt antagonist Mediates Pluripotency and Stemness in Glioblastoma

Background: Chemotherapeutic resistance of glioblastoma has been attributed to a self-renewing subpopulation, the glioma stem cells (GSCs), which is known to be maintained by the Wnt β−catenin pathway. Our previous findings demonstrated that exogeneous addition of the Wnt antagonist, secreted fizzle...

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Veröffentlicht in:Cancers (Basel)
Hauptverfasser: Bhuvanalakshmi, Gurubharathi, Gamit, Naisarg, Patil, Manasi, Arfuso, Frank, Sethi, Gautam, Dharmarajan, Arun, Prem Kumar, Alan, Warrier, Sudha
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6356444/
https://ncbi.nlm.nih.gov/pubmed/30591679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11010025
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