Secreted Frizzled-Related Protein 4 Inhibits Glioma Stem-Like Cells by Reversing Epithelial to Mesenchymal Transition, Inducing Apoptosis and Decreasing Cancer Stem Cell Properties

The Wnt pathway is integrally involved in regulating self-renewal, proliferation, and maintenance of cancer stem cells (CSCs). We explored the effect of the Wnt antagonist, secreted frizzled-related protein 4 (sFRP4), in modulating epithelial to mesenchymal transition (EMT) in CSCs from human gliobl...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: G, Bhuvanalakshmi, Arfuso, Frank, Millward, Michael, Dharmarajan, Arun, Warrier, Sudha
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4452329/
https://ncbi.nlm.nih.gov/pubmed/26030909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0127517
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