Transcriptional repression of IKKβ by p53 in arsenite-induced GADD45α accumulation and apoptosis

Our previous studies revealed that GADD45α is a liable protein, which undergoes MDM2-dependent constitutive ubiquitination and degradation in resting HepG2 hepatoma cells. Arsenite exposure induces ribosomal stress responses mediated by the ribosomal protein S7, which can block MDM2 activity and res...

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Publicado en:Oncogene
Main Authors: Hu, Yongliang, Jin, Rui, Gao, Ming, Xu, Huan, Zou, Shuxian, Li, Xiaoguang, Xing, Chen, Wang, Qiyu, Wang, Hongli, Feng, Jiannan, Hu, Meiru, Song, Lun
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355650/
https://ncbi.nlm.nih.gov/pubmed/30177839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0478-7
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