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Transcriptional repression of IKKβ by p53 in arsenite-induced GADD45α accumulation and apoptosis
Our previous studies revealed that GADD45α is a liable protein, which undergoes MDM2-dependent constitutive ubiquitination and degradation in resting HepG2 hepatoma cells. Arsenite exposure induces ribosomal stress responses mediated by the ribosomal protein S7, which can block MDM2 activity and res...
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| Publicado no: | Oncogene |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6355650/ https://ncbi.nlm.nih.gov/pubmed/30177839 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0478-7 |
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