Cardiac Ca(V)1.2 channels require β subunits for β-adrenergic–mediated modulation but not trafficking

Ca(2+) channel β-subunit interactions with pore-forming α-subunits are long-thought to be obligatory for channel trafficking to the cell surface and for tuning of basal biophysical properties in many tissues. Unexpectedly, we demonstrate that transgenic expression of mutant α(1C) subunits lacking ca...

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Vydáno v:J Clin Invest
Hlavní autoři: Yang, Lin, Katchman, Alexander, Kushner, Jared, Kushnir, Alexander, Zakharov, Sergey I., Chen, Bi-xing, Shuja, Zunaira, Subramanyam, Prakash, Liu, Guoxia, Papa, Arianne, Roybal, Daniel, Pitt, Geoffrey S., Colecraft, Henry M., Marx, Steven O.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2019
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355231/
https://ncbi.nlm.nih.gov/pubmed/30422117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI123878
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