Cardiac Ca(V)1.2 channels require β subunits for β-adrenergic–mediated modulation but not trafficking

Ca(2+) channel β-subunit interactions with pore-forming α-subunits are long-thought to be obligatory for channel trafficking to the cell surface and for tuning of basal biophysical properties in many tissues. Unexpectedly, we demonstrate that transgenic expression of mutant α(1C) subunits lacking ca...

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Dades bibliogràfiques
Publicat a:J Clin Invest
Autors principals: Yang, Lin, Katchman, Alexander, Kushner, Jared, Kushnir, Alexander, Zakharov, Sergey I., Chen, Bi-xing, Shuja, Zunaira, Subramanyam, Prakash, Liu, Guoxia, Papa, Arianne, Roybal, Daniel, Pitt, Geoffrey S., Colecraft, Henry M., Marx, Steven O.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355231/
https://ncbi.nlm.nih.gov/pubmed/30422117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI123878
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