Cardiac Ca(V)1.2 channels require β subunits for β-adrenergic–mediated modulation but not trafficking

Ca(2+) channel β-subunit interactions with pore-forming α-subunits are long-thought to be obligatory for channel trafficking to the cell surface and for tuning of basal biophysical properties in many tissues. Unexpectedly, we demonstrate that transgenic expression of mutant α(1C) subunits lacking ca...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Yang, Lin, Katchman, Alexander, Kushner, Jared, Kushnir, Alexander, Zakharov, Sergey I., Chen, Bi-xing, Shuja, Zunaira, Subramanyam, Prakash, Liu, Guoxia, Papa, Arianne, Roybal, Daniel, Pitt, Geoffrey S., Colecraft, Henry M., Marx, Steven O.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355231/
https://ncbi.nlm.nih.gov/pubmed/30422117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI123878
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