Type I IFN blockade uncouples immunotherapy-induced antitumor immunity and autoimmune toxicity

Despite its success in treating melanoma and hematological malignancies, adoptive cell therapy (ACT) has had only limited effects in solid tumors. This is due in part to a lack of specific antigen targets, poor trafficking and infiltration, and immunosuppression in the tumor microenvironment. In thi...

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Bibliographische Detailangaben
Veröffentlicht in:J Clin Invest
Hauptverfasser: Walsh, Scott R., Bastin, Donald, Chen, Lan, Nguyen, Andrew, Storbeck, Christopher J., Lefebvre, Charles, Stojdl, David, Bramson, Jonathan L., Bell, John C., Wan, Yonghong
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355222/
https://ncbi.nlm.nih.gov/pubmed/30422820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI121004
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