HDAC Inhibition Suppresses Primary Immune Responses, Enhances Secondary Immune Responses, and Abrogates Autoimmunity During Tumor Immunotherapy

Histone deacetylase inhibitors (HDACi) can modulate innate antiviral responses and render tumors more susceptible to oncolytic viruses (OVs); however, their effects on adaptive immunity in this context are largely unknown. Our present study reveals an unexpected property of the HDACi MS-275 that enh...

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Autors principals: Bridle, Byram W, Chen, Lan, Lemay, Chantal G, Diallo, Jean-Simon, Pol, Jonathan, Nguyen, Andrew, Capretta, Alfredo, He, Rongqiao, Bramson, Jonathan L, Bell, John C, Lichty, Brian D, Wan, Yonghong
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2013
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616544/
https://ncbi.nlm.nih.gov/pubmed/23295947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.265
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