Type I IFN blockade uncouples immunotherapy-induced antitumor immunity and autoimmune toxicity

Despite its success in treating melanoma and hematological malignancies, adoptive cell therapy (ACT) has had only limited effects in solid tumors. This is due in part to a lack of specific antigen targets, poor trafficking and infiltration, and immunosuppression in the tumor microenvironment. In thi...

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Bibliografiske detaljer
Udgivet i:J Clin Invest
Main Authors: Walsh, Scott R., Bastin, Donald, Chen, Lan, Nguyen, Andrew, Storbeck, Christopher J., Lefebvre, Charles, Stojdl, David, Bramson, Jonathan L., Bell, John C., Wan, Yonghong
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355222/
https://ncbi.nlm.nih.gov/pubmed/30422820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI121004
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