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Type I IFN blockade uncouples immunotherapy-induced antitumor immunity and autoimmune toxicity

Despite its success in treating melanoma and hematological malignancies, adoptive cell therapy (ACT) has had only limited effects in solid tumors. This is due in part to a lack of specific antigen targets, poor trafficking and infiltration, and immunosuppression in the tumor microenvironment. In thi...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Clin Invest
Päätekijät: Walsh, Scott R., Bastin, Donald, Chen, Lan, Nguyen, Andrew, Storbeck, Christopher J., Lefebvre, Charles, Stojdl, David, Bramson, Jonathan L., Bell, John C., Wan, Yonghong
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Clinical Investigation 2018
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355222/
https://ncbi.nlm.nih.gov/pubmed/30422820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI121004
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