Tumor-conditional anti-CTLA4 uncouples antitumor efficacy from immunotherapy-related toxicity

While immune checkpoint blockade leads to potent antitumor efficacy, it also leads to immune-related adverse events in cancer patients. These toxicities stem from systemic immune activation resulting in inflammation of multiple organs, including the gastrointestinal tract, lung, and endocrine organs...

詳細記述

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書誌詳細
出版年:J Clin Invest
主要な著者: Pai, Chien-Chun Steven, Simons, Donald M., Lu, Xiaoqing, Evans, Michael, Wei, Junnian, Wang, Yung-hua, Chen, Mingyi, Huang, John, Park, Chanhyuk, Chang, Anthony, Wang, Jiaxi, Westmoreland, Susan, Beam, Christine, Banach, Dave, Bowley, Diana, Dong, Feng, Seagal, Jane, Ritacco, Wendy, Richardson, Paul L., Mitra, Soumya, Lynch, Grace, Bousquet, Pete, Mankovich, John, Kingsbury, Gillian, Fong, Lawrence
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Clinical Investigation 2018
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6307943/
https://ncbi.nlm.nih.gov/pubmed/30530991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI123391
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