Matrix stiffness regulates vascular integrity through focal adhesion kinase activity

Tumor vasculature is known to be more permeable than the vasculature found in healthy tissue, which in turn can lead to a more aggressive tumor phenotype and impair drug delivery into tumors. While the stiffening of the stroma surrounding solid tumors has been reported to increase vascular permeabil...

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Bibliographic Details
Published in:FASEB J
Main Authors: Wang, Wenjun, Lollis, Emmanuel M., Bordeleau, François, Reinhart-King, Cynthia A.
Format: Artigo
Language:Inglês
Published: Federation of American Societies for Experimental Biology 2019
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355084/
https://ncbi.nlm.nih.gov/pubmed/30102569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201800841R
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