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Simvastatin Ameliorates Matrix Stiffness-Mediated Endothelial Monolayer Disruption
Arterial stiffening accompanies both aging and atherosclerosis, and age-related stiffening of the arterial intima increases RhoA activity and cell contractility contributing to increased endothelium permeability. Notably, statins are 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibito...
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| Publicado en: | PLoS One |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4712048/ https://ncbi.nlm.nih.gov/pubmed/26761203 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0147033 |
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