Transient activation of AMPK preceding left ventricular pressure overload reduces adverse remodeling and preserves left ventricular function

Coordinated changes in signaling pathways and gene expression in hearts subjected to prolonged stress maintain cardiac function. Loss of steroid receptor coactivator-2 (SRC-2) results in a reversal to the fetal gene program and disrupts the response to pressure overload, accompanied by prominent eff...

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Vydáno v:FASEB J
Hlavní autoři: Nam, Deok Hwa, Kim, Eunah, Benham, Ashley, Park, Hye-Kyung, Soibam, Benjamin, Taffet, George E., Kaelber, Jason T., Suh, Ji Ho, Taegtmeyer, Heinrich, Entman, Mark L., Reineke, Erin L.
Médium: Artigo
Jazyk:Inglês
Vydáno: Federation of American Societies for Experimental Biology 2019
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355077/
https://ncbi.nlm.nih.gov/pubmed/30024790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201800602R
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