Gene expression profiling of homologous recombination repair pathway indicates susceptibility for olaparib treatment in malignant pleural mesothelioma in vitro

BACKGROUND: Malignant pleural mesothelioma (MPM) is a tumour arising from pleural cavities with poor prognosis. Multimodality treatment with pemetrexed combined with cisplatin shows unsatisfying response-rates of 40%. The reasons for the rather poor efficacy of chemotherapeutic treatment are largely...

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Vydáno v:BMC Cancer
Hlavní autoři: Borchert, Sabrina, Wessolly, Michael, Schmeller, Jan, Mairinger, Elena, Kollmeier, Jens, Hager, Thomas, Mairinger, Thomas, Herold, Thomas, Christoph, Daniel C., Walter, Robert F. H., Eberhardt, Wilfried E. E., Plönes, Till, Wohlschlaeger, Jeremias, Aigner, Clemens, Schmid, Kurt Werner, Mairinger, Fabian D.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6354412/
https://ncbi.nlm.nih.gov/pubmed/30700254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-019-5314-0
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