Impact of metallothionein-knockdown on cisplatin resistance in malignant pleural mesothelioma

Malignant pleural mesothelioma (MPM) is a rare, but aggressive tumor with dismal prognosis. Platinum-based chemotherapy is regularly used as part of multimodality therapy. The expression of metallothioneins (MT) has been identified as a reason for cisplatin resistance, which often leads to early the...

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Published in:Sci Rep
Main Authors: Borchert, Sabrina, Suckrau, Pia-Maria, Walter, Robert F. H., Wessolly, Michael, Mairinger, Elena, Steinborn, Julia, Hegedus, Balazs, Hager, Thomas, Herold, Thomas, Eberhardt, Wilfried E. E., Wohlschlaeger, Jeremias, Aigner, Clemens, Bankfalvi, Agnes, Schmid, Kurt Werner, Mairinger, Fabian D.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7596082/
https://ncbi.nlm.nih.gov/pubmed/33122816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-75807-x
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