Inhibition of MDM2 via Nutlin-3A: A Potential Therapeutic Approach for Pleural Mesotheliomas with MDM2-Induced Inactivation of Wild-Type P53

Previously, our group demonstrated that nuclear expression of E3 ubiquitin ligase (MDM2) in malignant pleural mesothelioma (MPM) is significantly associated with decreased overall survival. A possible explanation may be that overexpression of MDM2 leads to a proteasomal degradation of TP53 that even...

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Detalhes bibliográficos
Publicado no:J Oncol
Main Authors: Walter, Robert F. H., Werner, Robert, Wessolly, Michael, Mairinger, Elena, Borchert, Sabrina, Schmeller, Jan, Kollmeier, Jens, Mairinger, Thomas, Hager, Thomas, Bankfalvi, Agnes, Christoph, Daniel C., Eberhardt, Wilfried E. E., Plönes, Till, Aigner, Clemens, Schmid, Kurt W., Wohlschlaeger, Jeremias, Mairinger, Fabian D.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6077509/
https://ncbi.nlm.nih.gov/pubmed/30112000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/1986982
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