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Inhibition of MDM2 via Nutlin-3A: A Potential Therapeutic Approach for Pleural Mesotheliomas with MDM2-Induced Inactivation of Wild-Type P53

Previously, our group demonstrated that nuclear expression of E3 ubiquitin ligase (MDM2) in malignant pleural mesothelioma (MPM) is significantly associated with decreased overall survival. A possible explanation may be that overexpression of MDM2 leads to a proteasomal degradation of TP53 that even...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:J Oncol
Main Authors: Walter, Robert F. H., Werner, Robert, Wessolly, Michael, Mairinger, Elena, Borchert, Sabrina, Schmeller, Jan, Kollmeier, Jens, Mairinger, Thomas, Hager, Thomas, Bankfalvi, Agnes, Christoph, Daniel C., Eberhardt, Wilfried E. E., Plönes, Till, Aigner, Clemens, Schmid, Kurt W., Wohlschlaeger, Jeremias, Mairinger, Fabian D.
פורמט: Artigo
שפה:Inglês
יצא לאור: Hindawi 2018
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC6077509/
https://ncbi.nlm.nih.gov/pubmed/30112000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/1986982
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