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ATP-gated P2X7 receptors require chloride channels to promote inflammation in human macrophages
Immune cells of myeloid origin show robust expression of ATP-gated P2X7 receptors, two-transmembrane ion channels permeable to Na(+), K(+), and Ca(2+). Receptor activation promotes inflammasome activation and release of the proinflammatory cytokines IL-1β and IL-18. Here, we show that ATP generates...
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| Publicado no: | J Immunol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6352910/ https://ncbi.nlm.nih.gov/pubmed/30598517 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1801101 |
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