Resistance to epigenetic-targeted therapy engenders tumor cell vulnerabilities associated with enhancer remodeling

Drug resistance represents a major challenge to achieving durable responses to cancer therapeutics. Resistance mechanisms to epigenetically-targeted drugs remain largely unexplored. We used BET inhibition in neuroblastoma as a prototype to model resistance to chromatin modulatory therapeutics. Genom...

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Опубликовано в: :Cancer Cell
Главные авторы: Iniguez, Amanda Balboni, Alexe, Gabriela, Wang, Emily Jue, Roti, Giovanni, Patel, Sarvagna, Chen, Liying, Kitara, Samuel, Conway, Amy, Robichaud, Amanda L., Stolte, Björn, Bandopadhayay, Pratiti, Goodale, Amy, Pantel, Sasha, Lee, Yenarae, Cheff, Dorian M., Hall, Matthew D., Guha, Rajarshi, Davis, Mindy I., Menard, Marie, Nasholm, Nicole, Weiss, William A., Qi, Jun, Beroukhim, Rameen, Piccioni, Federica, Johannessen, Cory, Stegmaier, Kimberly
Формат: Artigo
Язык:Inglês
Опубликовано: 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6352909/
https://ncbi.nlm.nih.gov/pubmed/30537514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.11.005
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