MEDU-36. BCL2 FAMILY MEMBERS ATTENUATE RESPONSE OF MYC-DRIVEN MEDULLOBLASTOMAS TO BET-BROMODOMAIN INHIBITION

BACKGROUND: BET-bromodomain proteins bind to H3K27ac enhancers and recruit transcriptional proteins to facilitate the expression of genes. Inhibition of BET-bromodomain proteins shows preclinical promise for MYC-driven tumors such as medulloblastoma (MB), however the mechanism of action and means of...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Clymer, Jessica, Gionet, Gabrielle, Gonzalez, Elizabeth, Buchan, Graham, Qian, Kenin, Ho, Patricia, O’Rourke, Ryan, Balboni-Iniguez, Amanda, Stegmaier, Kimberley, Ligon, Keith, Piccioni, Federica, Johannessen, Cory, Beroukhim, Rameen, Bandopadhayay, Pratiti
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Medulloblastoma
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477445/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.194
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados