MEDU-36. BCL2 FAMILY MEMBERS ATTENUATE RESPONSE OF MYC-DRIVEN MEDULLOBLASTOMAS TO BET-BROMODOMAIN INHIBITION

BACKGROUND: BET-bromodomain proteins bind to H3K27ac enhancers and recruit transcriptional proteins to facilitate the expression of genes. Inhibition of BET-bromodomain proteins shows preclinical promise for MYC-driven tumors such as medulloblastoma (MB), however the mechanism of action and means of...

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Dettagli Bibliografici
Pubblicato in:Neuro Oncol
Autori principali: Clymer, Jessica, Gionet, Gabrielle, Gonzalez, Elizabeth, Buchan, Graham, Qian, Kenin, Ho, Patricia, O’Rourke, Ryan, Balboni-Iniguez, Amanda, Stegmaier, Kimberley, Ligon, Keith, Piccioni, Federica, Johannessen, Cory, Beroukhim, Rameen, Bandopadhayay, Pratiti
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2019
Soggetti:
Medulloblastoma
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477445/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.194
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