Genome-scale CRISPR-Cas9 screen identifies druggable dependencies in TP53 wild-type Ewing sarcoma

Ewing sarcoma is a pediatric cancer driven by EWS-ETS transcription factor fusion oncoproteins in an otherwise stable genomic background. The majority of tumors express wild-type TP53, and thus, therapies targeting the p53 pathway would benefit most patients. To discover targets specific for TP53 wi...

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Publicado en:J Exp Med
Main Authors: Stolte, Björn, Iniguez, Amanda Balboni, Dharia, Neekesh V., Robichaud, Amanda L., Conway, Amy Saur, Morgan, Ann M., Alexe, Gabriela, Schauer, Nathan J., Liu, Xiaoxi, Bird, Gregory H., Tsherniak, Aviad, Vazquez, Francisca, Buhrlage, Sara J., Walensky, Loren D., Stegmaier, Kimberly
Formato: Artigo
Idioma:Inglês
Publicado: Rockefeller University Press 2018
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6080915/
https://ncbi.nlm.nih.gov/pubmed/30045945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20171066
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