EWS/FLI confers tumor cell synthetic lethality to CDK12 inhibition in Ewing sarcoma

Many cancer types are driven by oncogenic transcription factors that have been difficult to drug. Transcriptional inhibitors, however, may offer inroads into targeting these cancers. Through chemical genomics screening, we identified that Ewing sarcoma is a disease with preferential sensitivity to T...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Iniguez, Amanda Balboni, Stolte, Björn, Wang, Emily Jue, Conway, Amy Saur, Alexe, Gabriela, Dharia, Neekesh V., Kwiatkowski, Nicholas, Zhang, Tinghu, Abraham, Brian J., Mora, Jaume, Kalev, Peter, Leggett, Alan, Chowdhury, Dipanjan, Benes, Cyril H., Young, Richard A., Gray, Nathanael S., Stegmaier, Kimberly
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5846483/
https://ncbi.nlm.nih.gov/pubmed/29358035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.12.009
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