Impaired non-homologous end joining in human primary alveolar type II cells in emphysema

Emphysema is characterized by alveolar wall destruction induced mainly by cigarette smoke. Oxidative damage of DNA may contribute to the pathophysiology of this disease. We studied the impairment of the non-homologous end joining (NHEJ) repair pathway and DNA damage in alveolar type II (ATII) cells...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Kosmider, Beata, Lin, Chih-Ru, Vlasenko, Liudmila, Marchetti, Nathaniel, Bolla, Sudhir, Criner, Gerard J., Messier, Elise, Reisdorph, Nichole, Powell, Roger L., Madesh, Muniswamy, Kelsen, Steven, Xander, Nathaniel, Correll, Kelly A., Mason, Robert J., Bahmed, Karim
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6351635/
https://ncbi.nlm.nih.gov/pubmed/30696938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-37000-z
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