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Oleate disrupts cAMP signaling, contributing to potent stimulation of pancreatic β-cell autophagy
Autophagy is critical for maintaining cellular function via clearance of excess nutrients and damaged organelles. In pancreatic β-cells, it helps counter the endoplasmic reticulum (ER) stress that impairs insulin secretory capacity during Type 2 diabetes. Chronic exposure of β-cells to saturated fat...
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| Publicado no: | J Biol Chem |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6349129/ https://ncbi.nlm.nih.gov/pubmed/30518550 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004833 |
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