A comprehensive lipidomic screen of pancreatic β-cells using mass spectroscopy defines novel features of glucose-stimulated turnover of neutral lipids, sphingolipids and plasmalogens

OBJECTIVE: Glucose promotes lipid remodelling in pancreatic β-cells, and this is thought to contribute to the regulation of insulin secretion, but the metabolic pathways and potential signalling intermediates have not been fully elaborated. METHODS: Using mass spectrometry (MS) we quantified changes...

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Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Pearson, Gemma L., Mellett, Natalie, Chu, Kwan Yi, Boslem, Ebru, Meikle, Peter J., Biden, Trevor J.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4877660/
https://ncbi.nlm.nih.gov/pubmed/27257600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2016.04.003
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