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Tissue-Specific Chk1 Activation Determines Apoptosis by Regulating the Balance of p53 and p21
The DNA damage response (DDR) protects cells against genomic instability. Surprisingly, little is known about the differences in DDR across tissues, which may affect cancer evolutionary trajectories and chemotherapy response. Using mathematical modeling and quantitative experiments, we found that th...
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| 出版年: | iScience |
|---|---|
| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Elsevier
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6348202/ https://ncbi.nlm.nih.gov/pubmed/30665195 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2019.01.001 |
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