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Tissue-Specific Chk1 Activation Determines Apoptosis by Regulating the Balance of p53 and p21

The DNA damage response (DDR) protects cells against genomic instability. Surprisingly, little is known about the differences in DDR across tissues, which may affect cancer evolutionary trajectories and chemotherapy response. Using mathematical modeling and quantitative experiments, we found that th...

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Detalhes bibliográficos
Publicado no:iScience
Main Authors: van Jaarsveld, Marijn T.M., Deng, Difan, Wiemer, Erik A.C., Zi, Zhike
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6348202/
https://ncbi.nlm.nih.gov/pubmed/30665195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2019.01.001
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