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p53 and p21 Determine the Sensitivity of Noscapine-Induced Apoptosis in Colon Cancer Cells

We have previously discovered the naturally occurring antitussive alkaloid noscapine as a tubulin-binding agent that attenuates microtubule dynamics and arrests mammalian cells at mitosis via activation of the c-Jun NH(2)-terminal kinase pathway. It is well established that the p53 protein plays a c...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Aneja, Ritu, Ghaleb, Amr M., Zhou, Jun, Yang, Vincent W., Joshi, Harish C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3757339/
https://ncbi.nlm.nih.gov/pubmed/17440101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-06-4282
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