Chemoprevention of Familial Adenomatous Polyposis by Bromo-noscapine (EM011) in the Apc(Min/+) Mouse Model

Germline mutation of the tumor suppressor gene, adenomatous polyposis coli (APC), is responsible for familial adenomatous polyposis (FAP) with nearly 100% risk for colon cancer at an early age. Although FAP is involved in only 1% of all colon cancer cases, over 80% of sporadic cancers harbor somatic...

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Huvudupphovsmän: Li, Shiwang, Ghaleb, Amr M., He, Jing, Bughani, Usha, Bialkowska, Agnieszka B., Yang, Vincent W., Joshi, Harish C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3362662/
https://ncbi.nlm.nih.gov/pubmed/22052467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.27344
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