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Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are associated with loss of nuclear TDP-43. Here we identify that TDP-43 regulates expression of the neuronal growth-associated factor stathmin-2. Lowered TDP-43 levels, which reduce its binding to sites within the first intron of...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Nat Neurosci |
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| Κύριοι συγγραφείς: | , , , , , , , , , , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2019
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6348009/ https://ncbi.nlm.nih.gov/pubmed/30643298 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-018-0293-z |
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