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The RNA degradosome promotes tRNA quality control through clearance of hypomodified tRNA

The factors and mechanisms that govern tRNA stability in bacteria are not well understood. Here, we investigated the influence of posttranscriptional modification of bacterial tRNAs (tRNA modification) on tRNA stability. We focused on ThiI-generated 4-thiouridine (s(4)U), a modification found in bac...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Kimura, Satoshi, Waldor, Matthew K.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2019
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6347707/
https://ncbi.nlm.nih.gov/pubmed/30622183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1814130116
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