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Comparative tRNA sequencing and RNA mass spectrometry for surveying tRNA modifications

Chemical modifications of the nucleosides that comprise tRNAs are diverse. However, the structure, location, and extent of modifications have been systematically charted in very few organisms. Here, we describe an approach in which rapid prediction of modified sites through reverse transcription-der...

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Bibliographic Details
Published in:Nat Chem Biol
Main Authors: Kimura, Satoshi, Dedon, Peter C., Waldor, Matthew K.
Format: Artigo
Language:Inglês
Published: 2020
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8172280/
https://ncbi.nlm.nih.gov/pubmed/32514182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-020-0558-1
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