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The RNA degradosome promotes tRNA quality control through clearance of hypomodified tRNA

The factors and mechanisms that govern tRNA stability in bacteria are not well understood. Here, we investigated the influence of posttranscriptional modification of bacterial tRNAs (tRNA modification) on tRNA stability. We focused on ThiI-generated 4-thiouridine (s(4)U), a modification found in bac...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Kimura, Satoshi, Waldor, Matthew K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6347707/
https://ncbi.nlm.nih.gov/pubmed/30622183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1814130116
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