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The RNA degradosome promotes tRNA quality control through clearance of hypomodified tRNA

The factors and mechanisms that govern tRNA stability in bacteria are not well understood. Here, we investigated the influence of posttranscriptional modification of bacterial tRNAs (tRNA modification) on tRNA stability. We focused on ThiI-generated 4-thiouridine (s(4)U), a modification found in bac...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Kimura, Satoshi, Waldor, Matthew K.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6347707/
https://ncbi.nlm.nih.gov/pubmed/30622183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1814130116
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