RAE1 promotes BMAL1 shuttling and regulates degradation and activity of CLOCK: BMAL1 heterodimer

Circadian rhythm is an autoregulatory rhythm, which is sustained by various mechanisms. The nucleocytoplasmic shuttling of BMAL1 is essential for CLOCK translocation between cytoplasm and nucleus and maintenance of the correct pace of the circadian clock. Here we showed that RAE1 and NUP98 can promo...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Zheng, Xulei, Zhao, Xu, Zhang, Yingying, Tan, Hao, Qiu, Bojun, Ma, Tengjiao, Zeng, Jiarong, Tao, Dachang, Liu, Yunqiang, Lu, Yilu, Ma, Yongxin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6347605/
https://ncbi.nlm.nih.gov/pubmed/30683868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1346-2
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