RAE1 promotes BMAL1 shuttling and regulates degradation and activity of CLOCK: BMAL1 heterodimer

Circadian rhythm is an autoregulatory rhythm, which is sustained by various mechanisms. The nucleocytoplasmic shuttling of BMAL1 is essential for CLOCK translocation between cytoplasm and nucleus and maintenance of the correct pace of the circadian clock. Here we showed that RAE1 and NUP98 can promo...

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Dettagli Bibliografici
Pubblicato in:Cell Death Dis
Autori principali: Zheng, Xulei, Zhao, Xu, Zhang, Yingying, Tan, Hao, Qiu, Bojun, Ma, Tengjiao, Zeng, Jiarong, Tao, Dachang, Liu, Yunqiang, Lu, Yilu, Ma, Yongxin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6347605/
https://ncbi.nlm.nih.gov/pubmed/30683868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1346-2
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