RAE1 promotes BMAL1 shuttling and regulates degradation and activity of CLOCK: BMAL1 heterodimer

Circadian rhythm is an autoregulatory rhythm, which is sustained by various mechanisms. The nucleocytoplasmic shuttling of BMAL1 is essential for CLOCK translocation between cytoplasm and nucleus and maintenance of the correct pace of the circadian clock. Here we showed that RAE1 and NUP98 can promo...

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Publicat a:Cell Death Dis
Autors principals: Zheng, Xulei, Zhao, Xu, Zhang, Yingying, Tan, Hao, Qiu, Bojun, Ma, Tengjiao, Zeng, Jiarong, Tao, Dachang, Liu, Yunqiang, Lu, Yilu, Ma, Yongxin
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6347605/
https://ncbi.nlm.nih.gov/pubmed/30683868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1346-2
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