PIWIL1 destabilizes microtubule by suppressing phosphorylation at Ser16 and RLIM-mediated degradation of stathmin1

Human PIWIL1, alias HIWI, is a member of Piwi protein family and expressed in various tumors. However, the underlying mechanism of PIWIL1 in tumorigenesis remains largely unknown. Stathmin1 is a cytosolic phosphoprotein which has a critical role in regulating microtubule dynamics and is overexpresse...

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Pubblicato in:Oncotarget
Autori principali: Li, Chao, Zhou, Xiaoyan, Chen, Jianhui, Lu, Yilu, Sun, Qianqian, Tao, Dachang, Hu, Wei, Zheng, Xulei, Bian, Shasha, Liu, Yunqiang, Ma, Yongxin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2015
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4695026/
https://ncbi.nlm.nih.gov/pubmed/26317901
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