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HILI destabilizes microtubules by suppressing phosphorylation and Gigaxonin-mediated degradation of TBCB
Human PIWIL2, aka HILI, is a member of PIWI protein family and overexpresses in various tumors. However, the underlying mechanisms of HILI in tumorigenesis remain largely unknown. TBCB has a critical role in regulating microtubule dynamics and is overexpressed in many cancers. Here we report that HI...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5385498/ https://ncbi.nlm.nih.gov/pubmed/28393858 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep46376 |
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