Discovery and characterization of potent IL-21 neutralizing antibodies via a novel alternating antigen immunization and humanization strategy

Interleukin-21 (IL-21), a member of the common cytokine receptor γ chain (γ(c)) family, is secreted by CD4(+) T cells and natural killer T cells and induces effector function through interactions with the IL-21 receptor (IL-21R)/γ(c) complex expressed on both immune and non-immune cells. Numerous st...

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Bibliographic Details
Published in:PLoS One
Main Authors: Varkey, Reena, Du, Qun, Karnell, Jodi L., Xiao, Xiaodong, Casey, Kerry A., Woods, Rob, Rosenthal, Kim, Wilson, Susan, Dall’Acqua, William F., Wu, Herren, Herbst, Ronald, Ettinger, Rachel, Damschroder, Melissa
Format: Artigo
Language:Inglês
Published: Public Library of Science 2019
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6347146/
https://ncbi.nlm.nih.gov/pubmed/30682117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0211236
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