PD-L1 Expression in Circulating Tumor Cells Increases during Radio(chemo)therapy and Indicates Poor Prognosis in Non-small Cell Lung Cancer

Preclinical studies demonstrated that radiation up-regulates PD-L1 expression in tumor cells, providing a rationale for combining PD-1/PD-L1 inhibitors with radiation. However this has not been validated in patients with non-small cell lung cancer due to the difficulty to obtain serial biopsies. Mea...

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Publicat a:Sci Rep
Autors principals: Wang, Yang, Kim, Tae Hyun, Fouladdel, Shamileh, Zhang, Zhuo, Soni, Payal, Qin, Angel, Zhao, Lili, Azizi, Ebrahim, Lawrence, Theodore S., Ramnath, Nithya, Cuneo, Kyle C., Nagrath, Sunitha
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6345864/
https://ncbi.nlm.nih.gov/pubmed/30679441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-36096-7
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