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Development of a peptide-siRNA nanocomplex targeting NF- κB for efficient cartilage delivery
Delivery of therapeutic small interfering RNAs (siRNAs) in an effective dose to articular cartilage is very challenging as the cartilage dense extracellular matrix renders the chondrocytes inaccessible, even to intra-articular injections. Herein, we used a self-assembling peptidic nanoparticle (NP)...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6345850/ https://ncbi.nlm.nih.gov/pubmed/30679644 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-37018-3 |
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