Suppression of NF-κB activity via nanoparticle-based siRNA delivery alters early cartilage responses to injury

Osteoarthritis (OA) is a major cause of disability and morbidity in the aging population. Joint injury leads to cartilage damage, a known determinant for subsequent development of posttraumatic OA, which accounts for 12% of all OA. Understanding the early molecular and cellular responses postinjury...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Yan, Huimin, Duan, Xin, Pan, Hua, Holguin, Nilsson, Rai, Muhammad Farooq, Akk, Antonina, Springer, Luke E., Wickline, Samuel A., Sandell, Linda J., Pham, Christine T. N.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5068304/
https://ncbi.nlm.nih.gov/pubmed/27681622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1608245113
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