Quantitative fluorescence imaging determines the absolute number of locked nucleic acid oligonucleotides needed for suppression of target gene expression

Locked nucleic acid based antisense oligonucleotides (LNA-ASOs) can reach their intracellular RNA targets without delivery modules. Functional cellular uptake involves vesicular accumulation followed by translocation to the cytosol and nucleus. However, it is yet unknown how many LNA-ASO molecules n...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Buntz, Annette, Killian, Tobias, Schmid, Daniela, Seul, Heike, Brinkmann, Ulrich, Ravn, Jacob, Lindholm, Marie, Knoetgen, Hendrik, Haucke, Volker, Mundigl, Olaf
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
RNA and RNA-protein complexes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6344898/
https://ncbi.nlm.nih.gov/pubmed/30462278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky1158
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