The OTUD5–UBR5 complex regulates FACT-mediated transcription at damaged chromatin

Timely stalling and resumption of RNA polymerases at damaged chromatin are actively regulated processes. Prior work showed an importance of FACT histone chaperone in such process. Here we provide a new role of OTUD5 deubiquitinase in the FACT-dependent process. Through a DUB RNAi screen, we found OT...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: de Vivo, Angelo, Sanchez, Anthony, Yegres, Jose, Kim, Jeonghyeon, Emly, Sylvia, Kee, Younghoon
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2019
Schlagworte:
Gene regulation, Chromatin and Epigenetics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6344881/
https://ncbi.nlm.nih.gov/pubmed/30508113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky1219
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