MEHMO syndrome mutation EIF2S3-I259M impairs initiator Met-tRNA(i)(Met) binding to eukaryotic translation initiation factor eIF2

Eitemau Tebyg

• Initiation Factor eIF2γ Promotes eIF2–GTP–Met-tRNA(i)(Met) Ternary Complex Binding to the 40S Ribosome
  gan: Shin, Byung-Sik, et al.
  Cyhoeddwyd: (2011)
• Modulation of tRNA(iMet), eIF-2, and eIF-2B expression shows that GCN4 translation is inversely coupled to the level of eIF-2.GTP.Met-tRNA(iMet) ternary complexes.
  gan: Dever, T E, et al.
  Cyhoeddwyd: (1995)
• A multifactor complex of eukaryotic initiation factors, eIF1, eIF2, eIF3, eIF5, and initiator tRNA(Met) is an important translation initiation intermediate in vivo
  gan: Asano, Katsura, et al.
  Cyhoeddwyd: (2000)
• Initiation factor eIF5B catalyzes second GTP-dependent step in eukaryotic translation initiation
  gan: Lee, Joon H., et al.
  Cyhoeddwyd: (2002)
• Mutations in the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2 alpha) that overcome the inhibitory effect of eIF-2 alpha phosphorylation on translation initiation.
  gan: Vazquez de Aldana, C R, et al.
  Cyhoeddwyd: (1993)