Degenerate minigene library analysis enables identification of altered branch point utilization by mutant splicing factor 3B1 (SF3B1)

Cancer-associated mutations of the core splicing factor 3 B1 (SF3B1) result in selection of novel 3′ splice sites (3′SS), but precise molecular mechanisms of oncogenesis remain unclear. SF3B1 stabilizes the interaction between U2 snRNP and branch point (BP) on the pre-mRNA. It has hence been specula...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Nucleic Acids Res
Päätekijät: Gupta, Abhishek K, Murthy, Tushar, Paul, Kiran V, Ramirez, Oscar, Fisher, Joseph B, Rao, Sridhar, Rosenberg, Alexander B, Seelig, Georg, Minella, Alex C, Pillai, Manoj M
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2019
Aiheet:
RNA and RNA-protein complexes
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6344872/
https://ncbi.nlm.nih.gov/pubmed/30462273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky1161
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