Cyclin-dependent kinase 1 (CDK1) and CDK2 have opposing roles in regulating interactions of splicing factor 3B1 with chromatin

Splicing factor 3B1 (SF3B1) is a core splicing protein that stabilizes the interaction between the U2 snRNA and the branch point in the mRNA target during splicing. SF3B1 is heavily phosphorylated at its N terminus and a substrate of cyclin-dependent kinases (CDKs). Although SF3B1 phosphorylation co...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Murthy, Tushar, Bluemn, Theresa, Gupta, Abhishek K., Reimer, Michael, Rao, Sridhar, Pillai, Manoj M., Minella, Alex C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
DNA and Chromosomes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6028971/
https://ncbi.nlm.nih.gov/pubmed/29764937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.001654
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