Degenerate minigene library analysis enables identification of altered branch point utilization by mutant splicing factor 3B1 (SF3B1)

Cancer-associated mutations of the core splicing factor 3 B1 (SF3B1) result in selection of novel 3′ splice sites (3′SS), but precise molecular mechanisms of oncogenesis remain unclear. SF3B1 stabilizes the interaction between U2 snRNP and branch point (BP) on the pre-mRNA. It has hence been specula...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: Gupta, Abhishek K, Murthy, Tushar, Paul, Kiran V, Ramirez, Oscar, Fisher, Joseph B, Rao, Sridhar, Rosenberg, Alexander B, Seelig, Georg, Minella, Alex C, Pillai, Manoj M
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2019
Teme:
RNA and RNA-protein complexes
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6344872/
https://ncbi.nlm.nih.gov/pubmed/30462273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky1161
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