Cancer associated SF3B1 mutants recognize otherwise inaccessible cryptic 3’ splice sites within RNA secondary structures

Recurrent mutations in core splicing factors have been reported in several clonal disorders, including cancers. Mutations in SF3B1, a component of the U2 splicing complex, are the most common. SF3B1 mutations are associated with aberrant pre-mRNA splicing using cryptic 3’ splice sites (3’SS) but the...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Kesarwani, Anil K., Ramirez, Oscar, Gupta, Abhishek K., Yang, Xiaodong, Murthy, Tushar, Minella, Alex C., Pillai, Manoj M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5311031/
https://ncbi.nlm.nih.gov/pubmed/27524419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.279
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